Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 18/20 | 0.69 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16617845 | 1.00 | PTGER3 (0.69) | PTGER3CDK8CCNCCDK19 | |
| SCHEMBL16617784 | 0.90 | PTGER3 (0.69) | PTGER3CDK8CCNCCDK19 | |
| SCHEMBL16617783 | 0.90 | PTGER3 (0.69) | PTGER3CDK8CCNCCDK19 | |
| SCHEMBL16617681 | 0.89 | PTGER3 (0.69) | PTGER3CDK8CCNCCDK19 | |
| SCHEMBL16617680 | 0.89 | PTGER3 (0.69) | PTGER3CDK8CCNCCDK19 | |
| SCHEMBL16617863 | 0.89 | PTGER3 (0.71) | PTGER3 | |
| SCHEMBL16617864 | 0.89 | PTGER3 (0.71) | PTGER3 | |
| SCHEMBL16617140 | 0.84 | PTGER3 (0.68) | PTGER3CDK8CCNCCDK19 | |
| SCHEMBL16617137 | 0.84 | PTGER3 (0.68) | PTGER3CDK8CCNCCDK19 | |
| SCHEMBL19921887 | 0.82 | PTGER3 (1.00) | PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055300-B1 | ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR | PFIZER (US) | 2018-03-07 | — | — | EP | disclosed |
| US-9278953-B2 | Antagonists of prostaglandin EP3 receptor | PFIZER INC. (US) | 2016-03-08 | — | — | US | disclosed |
| US-20150099782-A1 | ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR | PFIZER INC. (US) | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099782-A1 | ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR | PTGER3, PTGES3, PTGER2 | PTGER3 1/4885CDK8 2876/4885CCNC 4095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.