SCHEMBL16618272

SCHEMBL16618272

[CH2]c1ncc(-c2ccc(C(=O)NS(C)(=O)=O)cc2OC)cc1Cl

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.71
SCN5A Q14524 5/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16618260 0.89 SCN9A (0.76) SCN9ASCN5A
SCHEMBL16618274 0.88 SCN9A (0.74) SCN9ASCN5A
SCHEMBL16618371 0.87 SCN9A (0.75) SCN9ASCN5A
SCHEMBL16618403 0.86 SCN9A (0.70) SCN9ASCN5A
SCHEMBL16618301 0.86 SCN9A (0.78) SCN9ASCN5A
SCHEMBL16618468 0.85 SCN9A (0.76) SCN9ASCN5A
SCHEMBL17940369 0.83 SCN9A (1.00) SCN9ASCN5A
SCHEMBL17940405 0.83 SCN9A (1.00) SCN9ASCN5A
SCHEMBL16618261 0.83 SCN9A (1.00) SCN9ASCN5A
SCHEMBL17940271 0.83 SCN9A (1.00) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015051043-A1 BIARYL ACYL-SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS AMGEN INC. (US) 2015-04-09 WO disclosed