Known targets — ChEMBL curated mechanism
ABL1BCRBLKEPHA2FGRFRKFYNHCKKITLCKLYNPDGFRBSRCSRMSYES1
The experimentally established mechanism targets of Dasatinib Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 known ✓ | P00519 | 10/20 | 1.00 |
| ▸ | SRC known ✓ | P12931 | 5/20 | 1.00 |
| ▸ | LCK known ✓ | P06239 | 4/20 | 1.00 |
| ▸ | FYN known ✓ | P06241 | 2/20 | 1.00 |
| ▸ | YES1 known ✓ | P07947 | 2/20 | 1.00 |
| ▸ | LYN known ✓ | P07948 | 2/20 | 1.00 |
| ▸ | HCK known ✓ | P08631 | 2/20 | 1.00 |
| ▸ | KIT known ✓ | P10721 | 2/20 | 1.00 |
| ▸ | BCR known ✓ | P11274 | 2/20 | 1.00 |
| ▸ | EPHA2 known ✓ | P29317 | 2/20 | 1.00 |
| ▸ | FRK known ✓ | P42685 | 2/20 | 1.00 |
| ▸ | PDGFRB known ✓ | P09619 | 1/20 | 1.00 |
| ▸ | FGR known ✓ | P09769 | 1/20 | 1.00 |
| ▸ | BLK known ✓ | P51451 | 1/20 | 1.00 |
| ▸ | SRMS known ✓ | Q9H3Y6 | 1/20 | 1.00 |
| ▸ | SIK2 | Q9H0K1 | 8/20 | 1.00 |
| ▸ | SIK3 | Q9Y2K2 | 8/20 | 1.00 |
| ▸ | SIK1 | P57059 | 6/20 | 1.00 |
| ▸ | PKMYT1 | Q99640 | 3/20 | 1.00 |
| ▸ | EPHB6 | O15197 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dasatinib Anhydrous SCHEMBL290515 | 1.00 | ABL1 (1.00) | ABL1SIK2SIK3SIK1SRC | |
| Dasatinib Anhydrous SCHEMBL16618224 | 1.00 | ABL1 (1.00) | ABL1SIK2SIK3SIK1SRC | |
| Dasatinib Anhydrous SCHEMBL29377489 | 1.00 | ABL1 (1.00) | ABL1SIK2SIK3SIK1SRC | |
| Dasatinib Anhydrous SCHEMBL29482416 | 1.00 | ABL1 (1.00) | ABL1SIK2SIK3SIK1SRC | |
| Dasatinib Anhydrous SCHEMBL16913911 | 0.99 | ABL1 (0.98) | ABL1SIK2SIK3SIK1SRC | |
| Dasatinib Anhydrous SCHEMBL29381185 | 0.99 | ABL1 (1.00) | ABL1SIK2SIK3SIK1SRC | |
| Dasatinib Anhydrous SCHEMBL8226 | 0.99 | ABL1 (1.00) | ABL1SIK2SIK3SIK1SRC | |
| Dasatinib Anhydrous SCHEMBL28350326 | 0.99 | ABL1 (1.00) | ABL1SIK2SIK3SIK1SRC | |
| Dasatinib Anhydrous SCHEMBL20857008 | 0.98 | ABL1 (0.98) | ABL1SIK2SIK3SIK1SRC | |
| Dasatinib Anhydrous SCHEMBL1705152 | 0.98 | ABL1 (0.98) | ABL1SIK2SIK3SIK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049645-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF DASATINIB | ALEMBIC PHARMACEUTICALS LIMITED (IN) | 2015-04-09 | — | — | WO | disclosed |