Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 18/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 7/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662151 | 0.92 | NPC1 (0.38) | S1PR1S1PR3NPC1PKMHPGD | |
| SCHEMBL1661938 | 0.90 | S1PR1 (0.51) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1662103 | 0.84 | S1PR1 (0.41) | S1PR1S1PR3S1PR5KDM4EALDH1A1 | |
| SCHEMBL1662147 | 0.82 | S1PR1 (0.48) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1662455 | 0.80 | S1PR1 (0.55) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1664282 | 0.77 | S1PR1 (0.46) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1662206 | 0.75 | S1PR1 (0.52) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1662100 | 0.74 | S1PR1 (0.52) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1661775 | 0.74 | S1PR1 (0.42) | S1PR1S1PR3 | |
| SCHEMBL1661683 | 0.72 | S1PR1 (0.65) | S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |