Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.57 |
| ▸ | S1PR3 | Q99500 | 14/20 | 0.57 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421718 | 0.91 | S1PR1 (0.62) | S1PR1S1PR3S1PR5DRD3 | |
| SCHEMBL1661156 | 0.89 | S1PR1 (0.70) | S1PR1S1PR3S1PR5DRD3 | |
| SCHEMBL1661833 | 0.87 | S1PR1 (0.58) | S1PR1S1PR3S1PR5DRD3 | |
| Trifluoroacetic Acid SCHEMBL1661948 | 0.81 | S1PR1 (0.71) | S1PR1S1PR3S1PR5DRD3 | |
| SCHEMBL3419377 | 0.80 | S1PR1 (0.63) | S1PR1S1PR3S1PR5DRD3 | |
| SCHEMBL1661153 | 0.80 | S1PR1 (0.76) | S1PR1S1PR3S1PR5DRD3 | |
| SCHEMBL3418259 | 0.79 | S1PR1 (0.81) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1661183 | 0.78 | S1PR1 (0.70) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1661579 | 0.77 | S1PR1 (0.81) | S1PR1S1PR3S1PR5DRD3 | |
| SCHEMBL1661381 | 0.75 | S1PR1 (0.69) | S1PR1S1PR3S1PR5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |