Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | BRAF | P15056 | 3/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.56 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 2/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11029731 | 0.88 | TLR8 (0.62) | KDRBRAFMAPK14TNNI3KCA12 | |
| SCHEMBL11002296 | 0.84 | TLR8 (0.62) | KDRBRAFMAPK14TNNI3KCA12 | |
| SCHEMBL16628083 | 0.84 | KDR (0.58) | KDRBRAFMAPK14TNNI3KCA12 | |
| SCHEMBL16621239 | 0.83 | EPHX2 (0.69) | KDRBRAFMAPK14TNNI3KCA12 | |
| SCHEMBL939205 | 0.83 | KDR (0.79) | KDRBRAFMAPK14TNNI3KCA12 | |
| SCHEMBL16621127 | 0.81 | MAPT (0.72) | KDRBRAFMAPK14TNNI3KCA12 | |
| SCHEMBL16621046 | 0.80 | KDR (0.67) | KDRBRAFMAPK14TNNI3KCA1 | |
| SCHEMBL11012192 | 0.79 | EPHX2 (0.76) | KDRBRAFMAPK14TNNI3KCA12 | |
| SCHEMBL16628077 | 0.79 | RAF1 (0.67) | KDRBRAFMAPK14TNNI3KCA12 | |
| SCHEMBL11001590 | 0.78 | EPHX2 (0.81) | KDRCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |