Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3994030 | 0.91 | EPHX2 (0.70) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL16628031 | 0.86 | RAF1 (0.61) | SMN1; SMN2LMNAEPHX2GAAHSD17B10 | |
| SCHEMBL16621099 | 0.83 | MAPT (0.71) | MAPTSMN1; SMN2LMNAHTTNPC1 | |
| SCHEMBL4005092 | 0.83 | EPHX2 (0.69) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL16628043 | 0.83 | HIF1A (0.69) | SMN1; SMN2MEN1KMT2AHTTEPHX2 | |
| SCHEMBL13528823 | 0.82 | KDR (0.60) | MAPTEPHX2 | |
| SCHEMBL4180664 | 0.81 | MAPT (0.65) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL4922234 | 0.80 | MAPT (0.73) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL5863121 | 0.80 | MAPT (0.73) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL1927233 | 0.80 | CSF1R (0.55) | MAPTLMNAMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |