Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.73 |
| ▸ | MTOR | P42345 | 15/20 | 0.66 |
| ▸ | RPTOR | Q8N122 | 15/20 | 0.66 |
| ▸ | MLST8 | Q9BVC4 | 15/20 | 0.66 |
| ▸ | RICTOR | Q6R327 | 13/20 | 0.66 |
| ▸ | MAPKAP1 | Q9BPZ7 | 13/20 | 0.66 |
| ▸ | PIK3R1 | P27986 | 11/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16625640 | 1.00 | PIK3CA (0.73) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL18431653 | 1.00 | PIK3CA (0.73) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL16625486 | 0.87 | PIK3CA (0.75) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL16625485 | 0.87 | PIK3CA (0.75) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL16625677 | 0.87 | PIK3CA (0.75) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL16625675 | 0.87 | PIK3CA (0.75) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL18431429 | 0.87 | PIK3CA (0.75) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL16625500 | 0.85 | PIK3CA (0.73) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL20708170 | 0.85 | PIK3CA (0.73) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL16625674 | 0.85 | PIK3CA (0.76) | PIK3CAMTORRPTORMLST8RICTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556203-B2 | Conformationally restricted P13K and mTOR inhibitors | PIQUR THERAPEUTICS AG (CH) | 2017-01-31 | — | — | US | claimed |
| US-20160244463-A1 | CONFORMATIONALLY RESTRICTED P13K AND MTOR INHIBITORS | TORQUR AG (CH) | 2016-08-25 | — | — | US | claimed |
| EP-3052504-B1 | CONFORMATIONALLY RESTRICTED PI3K AND MTOR INHIBITORS | UNIV BASEL (CH) | 2019-02-06 | — | — | EP | disclosed |
| EP-3052504-B1 | CONFORMATIONALLY RESTRICTED PI3K AND MTOR INHIBITORS | UNIV BASEL (CH) | 2019-02-06 | — | — | EP | disclosed |
| US-9556203-B2 | Conformationally restricted P13K and mTOR inhibitors | PIQUR THERAPEUTICS AG (CH) | 2017-01-31 | — | — | US | disclosed |
| US-9556203-B2 | Conformationally restricted P13K and mTOR inhibitors | PIQUR THERAPEUTICS AG (CH) | 2017-01-31 | — | — | US | disclosed |
| US-20160244463-A1 | CONFORMATIONALLY RESTRICTED P13K AND MTOR INHIBITORS | TORQUR AG (CH) | 2016-08-25 | — | — | US | disclosed |
| US-20160244463-A1 | CONFORMATIONALLY RESTRICTED P13K AND MTOR INHIBITORS | TORQUR AG (CH) | 2016-08-25 | — | — | US | disclosed |
| EP-3052504-A1 | CONFORMATIONALLY RESTRICTED PI3K AND MTOR INHIBITORS | Universität Basel (CH) | 2016-08-10 | — | — | EP | disclosed |
| WO-2015049369-A1 | CONFORMATIONALLY RESTRICTED PI3K AND MTOR INHIBITORS | UNIVERSITAET BASEL (CH) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015049369-A1 | CONFORMATIONALLY RESTRICTED PI3K AND MTOR INHIBITORS | UNIVERSITAET BASEL (CH) | 2015-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160244463-A1 | CONFORMATIONALLY RESTRICTED P13K AND MTOR INHIBITORS | MTOR, RICTOR, PIK3R4 | PIK3CA 15/4885MTOR 1/4885RPTOR 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.