Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MAP2 | P11137 | 2/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | DTYMK | P23919 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16621034 | 0.83 | CHRM2 (0.41) | CHRM3CHRM2CHRM4CHRM1MAP2 | |
| SCHEMBL16621139 | 0.81 | SLC7A11 (0.47) | CHRM3CHRM2CHRM4CHRM1 | |
| SCHEMBL16621133 | 0.78 | CHRM2 (0.37) | CHRM3CHRM2CHRM4CHRM1MAP2 | |
| SCHEMBL16620774 | 0.76 | CHRM2 (0.39) | CHRM3CHRM2CHRM4CHRM1MAP2 | |
| SCHEMBL5820725 | 0.66 | SLC6A4 (0.60) | CHRM2SLC6A2SLC6A4KCNH2 | |
| SCHEMBL30022454 | 0.65 | CHRM2 (0.59) | CHRM3CHRM2CHRM4CHRM1 | |
| SCHEMBL13696680 | 0.65 | CHRM2 (0.59) | CHRM3CHRM2CHRM4CHRM1 | |
| SCHEMBL2241939 | 0.63 | PTGS1 (0.49) | CHRM3CHRM2CHRM4CHRM1 | |
| SCHEMBL24554908 | 0.63 | CHRM2 (0.49) | CHRM3CHRM2CHRM4CHRM1 | |
| SCHEMBL19594148 | 0.63 | CHRM2 (0.49) | CHRM3CHRM2CHRM4CHRM1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |