Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980160 | 0.85 | MAPT (0.41) | MAPTMAPK1KDM4EALDH1A1GAA | |
| SCHEMBL20055030 | 0.78 | BRD4 (0.33) | MAPTMAPK1TDP1TP53L3MBTL1 | |
| SCHEMBL19885348 | 0.76 | MAPT (0.44) | MAPTMAPK1KDM4EALDH1A1GAA | |
| SCHEMBL2756591 | 0.75 | MAPK1 (0.36) | MAPTMAPK1KDM4EALDH1A1GAA | |
| SCHEMBL12841613 | 0.73 | MEN1 (0.44) | MAPTMAPK1KDM4EGAASMN1; SMN2 | |
| SCHEMBL2756790 | 0.72 | NR1H3 (0.34) | MAPTMAPK1KDM4EALDH1A1GAA | |
| SCHEMBL21507788 | 0.69 | MAPT (0.40) | MAPTMAPK1KDM4EALDH1A1GAA | |
| SCHEMBL4338325 | 0.67 | NPC1 (0.40) | MAPTMAPK1KDM4EALDH1A1GAA | |
| SCHEMBL10133829 | 0.67 | MAPT (0.38) | MAPTMAPK1KDM4EALDH1A1GAA | |
| SCHEMBL13070490 | 0.67 | GAA (0.39) | MAPTMAPK1KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857394-A1 | Antiviral compounds | Gilead Pharmasset LLC (US) | 2015-04-08 | — | — | EP | disclosed |