Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.37 |
| ▸ | ULK1 | O75385 | 5/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | LCAT | P04180 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15994053 | 0.85 | KDR (0.40) | KIF11PDE3BPDE3AIDH1LCAT | |
| SCHEMBL18168295 | 0.75 | IDH1 (0.42) | PDE3BPDE3ACRBNIDH1HTR1A | |
| SCHEMBL17541302 | 0.75 | ITGAV (0.35) | — | |
| SCHEMBL14042006 | 0.75 | PDE3B (0.46) | PDE3BPDE3ACRBNIDH1DDB1 | |
| SCHEMBL2574949 | 0.72 | PDE3B (0.38) | PDE3BPDE3ACRBNIDH1NPC1 | |
| SCHEMBL17164728 | 0.71 | PDE3B (0.40) | PDE3BPDE3ACRBNIDH1HTR1A | |
| SCHEMBL2625476 | 0.69 | PDE3B (0.41) | PDE3BPDE3AIDH1LCAT | |
| SCHEMBL2819230 | 0.69 | IDH1 (0.39) | PDE3BPDE3ACRBNIDH1HTR1A | |
| SCHEMBL14020816 | 0.68 | IDH1 (0.38) | PDE3BPDE3ACRBNIDH1HTR1A | |
| SCHEMBL3419723 | 0.67 | CRBN (0.47) | PDE3BPDE3ACRBNNPC1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491032-A1 | AKT INHIBITORS | Eli Lilly and Company (US) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011050016-A1 | AKT INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-04-28 | — | — | WO | disclosed |