Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 15/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612099 | 0.88 | PIK3CA (0.62) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16611531 | 0.87 | PIK3CA (0.57) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16611594 | 0.84 | PIK3CA (0.59) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16731016 | 0.83 | PIK3CA (0.59) | PIK3CAPIK3R1MTOR | |
| SCHEMBL16611751 | 0.82 | PIK3CA (0.63) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16727835 | 0.81 | PIK3CA (0.62) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16622894 | 0.81 | PIK3CA (0.60) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16611293 | 0.81 | PIK3CA (0.65) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16611050 | 0.81 | PIK3CA (0.72) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16611517 | 0.81 | PIK3CA (0.75) | PIK3CAPIK3R1MTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857403-A1 | PYRROLO[2,1-F][1,2,4]TRIAZINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2015-04-08 | — | — | EP | disclosed |