Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.83 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.74 |
| ▸ | MTOR | P42345 | 13/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16727837 | 0.92 | PIK3CA (0.74) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16611561 | 0.91 | PIK3CA (1.00) | PIK3CAPIK3R1MTOR | |
| SCHEMBL16727843 | 0.91 | PIK3CA (0.89) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16727838 | 0.90 | PIK3CA (0.84) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16727836 | 0.88 | PIK3CA (0.65) | PIK3CAPIK3R1MTOR | |
| SCHEMBL16611050 | 0.86 | PIK3CA (0.72) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL18356848 | 0.86 | PIK3CA (0.81) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16611569 | 0.85 | PIK3CA (1.00) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16727839 | 0.85 | PIK3CA (0.85) | PIK3CAPIK3R1MTORPIK3CG | |
| SCHEMBL16611681 | 0.83 | PIK3CA (0.86) | PIK3CAPIK3R1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857403-A1 | PYRROLO[2,1-F][1,2,4]TRIAZINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2015-04-08 | — | — | EP | disclosed |