Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.73 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.59 |
| ▸ | MTOR | P42345 | 6/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16611666 | 0.87 | PIK3CA (0.79) | PIK3CAPIK3R1MTORPIK3CDRAF1 | |
| SCHEMBL16622901 | 0.87 | PIK3CA (0.79) | PIK3CAPIK3R1MTORPIK3CDRAF1 | |
| SCHEMBL16611561 | 0.84 | PIK3CA (1.00) | PIK3CAPIK3R1MTORPIK3CDRAF1 | |
| SCHEMBL16622911 | 0.81 | PIK3CA (0.73) | PIK3CAPIK3R1MTORPIK3CDRAF1 | |
| SCHEMBL16727836 | 0.79 | PIK3CA (0.65) | PIK3CAPIK3R1MTORPIK3CD | |
| SCHEMBL18080823 | 0.78 | PIK3CA (0.65) | PIK3CAPIK3R1MTORPIK3CDRAF1 | |
| SCHEMBL16611061 | 0.78 | PIK3CA (0.84) | PIK3CAPIK3R1MTORPIK3CDRAF1 | |
| SCHEMBL16611681 | 0.78 | PIK3CA (0.86) | PIK3CAPIK3R1MTORPIK3CDRAF1 | |
| SCHEMBL16622899 | 0.76 | PIK3CA (0.81) | PIK3CAPIK3R1MTORPIK3CDRAF1 | |
| SCHEMBL16611835 | 0.76 | PIK3CA (1.00) | PIK3CAPIK3R1MTORPIK3CDRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857403-A1 | PYRROLO[2,1-F][1,2,4]TRIAZINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2015-04-08 | — | — | EP | disclosed |