Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.35 |
| ▸ | MTOR | P42345 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14806817 | 0.87 | PIK3CA (0.48) | FLT3YTHDC1PIK3CAMTORPIK3CD | |
| SCHEMBL114841 | 0.80 | PIK3CA (0.58) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL114549 | 0.79 | PIK3CA (0.59) | FLT3YTHDC1PIK3CAMTORPIK3CD | |
| SCHEMBL113367 | 0.78 | PIK3CA (0.44) | FLT3PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL114526 | 0.76 | PIK3CA (0.54) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL115335 | 0.75 | FLT3 (0.47) | FLT3PIK3CAMTOR | |
| SCHEMBL115718 | 0.74 | PIK3CA (0.45) | FLT3PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL116174 | 0.74 | PIK3CA (0.53) | FLT3PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL116075 | 0.73 | PIK3CA (0.51) | FLT3YTHDC1PIK3CAMTORPIK3CD | |
| SCHEMBL168592 | 0.73 | PIK3CA (0.46) | FLT3YTHDC1PIK3CAMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-B1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC (US) | 2015-04-08 | — | — | EP | disclosed |