SCHEMBL16623221

SCHEMBL16623221

C=CCN1CC(=O)N2[C@@H](C)C(=O)N(Cc3cccc(C(=O)Nc4cc[nH]n4)c3)C[C@@H]2N1C(=O)NCc1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 19/20 0.51
TCF4 P15884 1/20 0.47
CTNNB1 P35222 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12173482 0.89 CYP3A4 (0.63) CYP3A4
SCHEMBL763073 0.89 CYP3A4 (0.63) CYP3A4
SCHEMBL16623260 0.85 CYP3A4 (0.57) CYP3A4
SCHEMBL16623163 0.85 CYP3A4 (0.54) CYP3A4
SCHEMBL18411134 0.80 CYP3A4 (0.51) CYP3A4
SCHEMBL16623145 0.79 CYP3A4 (0.52) CYP3A4
SCHEMBL16623303 0.78 CYP3A4 (0.51) CYP3A4
SCHEMBL18411057 0.78 CYP3A4 (0.49) CYP3A4
SCHEMBL13028822 0.77 CYP3A4 (0.60) CYP3A4TCF4CTNNB1
SCHEMBL16623242 0.77 CYP3A4 (0.51) CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2212330-B1 NOVEL COMPOUNDS OF REVERSE TURN MIMETICS AND THE USE THEREOF (3) CHOONGWAE PHARMA CORP (KR) 2015-04-08 EP disclosed