SCHEMBL16624090

SCHEMBL16624090

CC(C)N1Cc2ccc(OC(F)F)cc2C(O)C1

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ACACB O00763 19/20 0.43
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16624024 0.85 SLC6A4 (0.48) ACACB
SCHEMBL18035003 0.84 SLC6A4 (0.44) ACACBALDH1A1
SCHEMBL16624031 0.82 ACACB (0.43) ACACB
SCHEMBL16624025 0.81 ACACB (0.49) ACACB
SCHEMBL16624050 0.81 ACACB (0.41) ACACB
SCHEMBL16624049 0.80 CYP17A1 (0.41) ACACB
SCHEMBL16624097 0.79 ACACB (0.56) ACACB
SCHEMBL17993844 0.77 SLC6A2 (0.44) ACACB
SCHEMBL16624039 0.77 DRD1 (0.39) ACACBALDH1A1
SCHEMBL16854833 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3053917-A1 T-TYPE CALCIUM CHANNEL BLOCKER Nissan Chemical Industries, Ltd. (JP) 2016-08-10 EP disclosed
WO-2015050212-A1 T-TYPE CALCIUM CHANNEL BLOCKER 日産化学工業株式会社 2015-04-09 WO disclosed