Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 10/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419823 | 0.86 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1ALDH1A1HPGDLMNA | |
| SCHEMBL8930907 | 0.85 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1ALDH1A1HPGDLMNA | |
| SCHEMBL420101 | 0.83 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1ALDH1A1HPGDLMNA | |
| SCHEMBL420065 | 0.83 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1ALDH1A1HPGDLMNA | |
| SCHEMBL419131 | 0.82 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1ALDH1A1HPGDLMNA | |
| SCHEMBL421158 | 0.81 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1ALDH1A1HPGDLMNA | |
| SCHEMBL14293304 | 0.80 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1ALDH1A1HPGDLMNA | |
| SCHEMBL8931075 | 0.80 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1ALDH1A1HPGDLMNA | |
| SCHEMBL419822 | 0.80 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1ALDH1A1HPGDLMNA | |
| SCHEMBL14344623 | 0.80 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1ALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150099721-A1 | TREATING CANCER WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2015-04-09 | — | — | US | disclosed |
| US-20150099721-A1 | TREATING CANCER WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099721-A1 | TREATING CANCER WITH HSP90 INHIBITORY COMPOUNDS | ROS1, RET, HSP90AB1 | HSP90AA1 4/4885HSP90AB1 3/4885ALDH1A1 733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.