Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | JAK1 | P23458 | 4/20 | 0.43 |
| ▸ | TYK2 | P29597 | 4/20 | 0.43 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | EIF4E | P06730 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 6/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29756374 | 0.91 | MKNK1 (0.56) | MKNK1MKNK2EIF4EMTORCFTR | |
| SCHEMBL16620919 | 0.91 | MKNK1 (0.56) | MKNK1MKNK2EIF4EMTORCFTR | |
| SCHEMBL17998743 | 0.89 | MTOR (0.48) | MKNK1MKNK2JAK2JAK1TYK2 | |
| Formic Acid SCHEMBL29756329 | 0.86 | MTOR (0.46) | MKNK1MKNK2JAK2JAK1TYK2 | |
| Formic Acid SCHEMBL16620929 | 0.86 | MTOR (0.46) | MKNK1MKNK2JAK2JAK1TYK2 | |
| SCHEMBL16621295 | 0.81 | MKNK1 (0.54) | MKNK1MKNK2EIF4E | |
| SCHEMBL16626042 | 0.81 | MKNK1 (0.59) | MKNK1MKNK2EIF4EMTORHPGD | |
| SCHEMBL16625832 | 0.80 | MTOR (0.50) | MKNK1MKNK2EIF4EMTORPIK3CA | |
| SCHEMBL16620715 | 0.80 | MTOR (0.52) | MKNK1MKNK2EIF4EMTORPIK3CA | |
| SCHEMBL29756323 | 0.79 | MKNK1 (0.60) | MKNK1MKNK2EIF4EMTORHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015050505-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-04-09 | — | — | WO | disclosed |