Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.49 |
| ▸ | GLB1 | P16278 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 2/20 | 0.31 |
| ▸ | EBP | Q15125 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13600634 | 0.93 | GBA1 (0.43) | GBA1GLB1LMNAGUSBEBP | |
| SCHEMBL13171644 | 0.86 | GBA1 (0.35) | GBA1SIGMAR1 | |
| SCHEMBL16625961 | 0.83 | GBA1 (0.42) | GBA1SIGMAR1 | |
| SCHEMBL14131035 | 0.81 | GBA1 (0.38) | GBA1 | |
| SCHEMBL24027422 | 0.79 | GBA1 (0.55) | GBA1GLB1LMNAGUSBEBP | |
| SCHEMBL14156508 | 0.77 | GBA1 (0.49) | GBA1GLB1LMNAGUSBEBP | |
| SCHEMBL16997015 | 0.77 | GBA1 (0.49) | GBA1GLB1LMNAGUSBEBP | |
| SCHEMBL23568426 | 0.77 | GBA1 (0.49) | GBA1GLB1LMNAGUSBEBP | |
| SCHEMBL9946206 | 0.76 | — | — | |
| SCHEMBL19165619 | 0.75 | DPP4 (0.36) | GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023164233-A1 | (4-BENZO[D]OXAZOL-2-YL)-6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-5(4H)-YL)METHANONE DERIVATIVES AS MUTANT PAH STABILIZERS FOR THE TREATMENT OF PHENYLKETONURIA | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2023164236-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2023164235-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2015050471-A1 | CARBAZOLE COMPOUNDS AND METHODS OF USING SAME | OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOST'YU "PANACELA LABS" (RU) | 2015-04-09 | — | — | WO | disclosed |