Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 10/20 | 0.63 |
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | EIF4E | P06730 | 3/20 | 0.53 |
| ▸ | GRM3 | Q14832 | 4/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16620923 | 0.90 | MKNK1 (0.63) | MKNK2MKNK1CYP3A4EIF4EGRM3 | |
| SCHEMBL17998777 | 0.87 | MKNK1 (0.65) | MKNK2MKNK1CYP3A4EIF4ECCNC | |
| SCHEMBL20365197 | 0.83 | MKNK1 (0.60) | MKNK2MKNK1CYP3A4EIF4ECCNC | |
| SCHEMBL16620734 | 0.82 | MKNK1 (0.60) | MKNK2MKNK1CYP3A4EIF4ECCNC | |
| SCHEMBL20365194 | 0.81 | MKNK1 (0.56) | MKNK2MKNK1CYP3A4EIF4ECCNC | |
| SCHEMBL17969602 | 0.80 | MKNK1 (0.66) | MKNK2MKNK1CYP3A4EIF4E | |
| SCHEMBL16620738 | 0.79 | MKNK1 (0.60) | MKNK2MKNK1CYP3A4EIF4E | |
| SCHEMBL29756323 | 0.79 | MKNK1 (0.60) | MKNK2MKNK1CYP3A4EIF4E | |
| SCHEMBL16620849 | 0.79 | MKNK1 (0.79) | MKNK2MKNK1CYP3A4EIF4E | |
| SCHEMBL16625987 | 0.79 | MKNK1 (0.65) | MKNK2MKNK1CYP3A4EIF4EPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015050505-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-04-09 | — | — | WO | disclosed |