Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 19/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 19/20 | 0.59 |
| ▸ | EIF4E | P06730 | 5/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16620670 | 0.84 | MKNK1 (0.49) | MKNK1MKNK2EIF4EPIK3CACYP3A4 | |
| SCHEMBL19243854 | 0.79 | MKNK1 (0.69) | MKNK1MKNK2EIF4EPIK3CACYP3A4 | |
| SCHEMBL16620931 | 0.75 | MKNK1 (0.49) | MKNK1MKNK2EIF4EPIK3CA | |
| SCHEMBL29756308 | 0.75 | MKNK1 (0.49) | MKNK1MKNK2EIF4EPIK3CA | |
| SCHEMBL15288375 | 0.73 | MKNK1 (0.80) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL16625991 | 0.73 | MKNK1 (0.52) | MKNK1MKNK2EIF4EPIK3CACYP3A4 | |
| SCHEMBL16626044 | 0.72 | MKNK1 (0.62) | MKNK1MKNK2EIF4EPIK3CACYP3A4 | |
| SCHEMBL16620455 | 0.72 | MKNK1 (0.38) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL16291234 | 0.70 | MKNK1 (0.74) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL29756458 | 0.70 | MKNK1 (0.54) | MKNK1MKNK2EIF4EPIK3CACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015050505-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-04-09 | — | — | WO | disclosed |