Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.49 |
| ▸ | JAK2 | O60674 | 13/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.43 |
| ▸ | JAK1 | P23458 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | TYK2 | P29597 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 2/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672049 | 0.88 | JAK3 (0.49) | JAK3JAK2HDAC6JAK1HDAC1 | |
| SCHEMBL12002572 | 0.86 | JAK3 (0.51) | JAK3JAK2HDAC6JAK1HDAC1 | |
| SCHEMBL672557 | 0.86 | JAK3 (0.51) | JAK3JAK2HDAC6JAK1HDAC1 | |
| SCHEMBL672905 | 0.85 | JAK3 (0.52) | JAK3JAK2HDAC6JAK1HDAC1 | |
| SCHEMBL671993 | 0.85 | JAK3 (0.52) | JAK3JAK2HDAC6JAK1HDAC1 | |
| SCHEMBL1662384 | 0.85 | JAK3 (0.53) | JAK3JAK2HDAC6JAK1HDAC1 | |
| SCHEMBL672030 | 0.84 | JAK3 (0.52) | JAK3JAK2HDAC6JAK1HDAC1 | |
| SCHEMBL10203360 | 0.84 | JAK3 (0.49) | JAK3JAK2HDAC6JAK1HDAC1 | |
| SCHEMBL27869402 | 0.84 | JAK3 (0.52) | JAK3JAK2HDAC6JAK1HDAC1 | |
| SCHEMBL27885714 | 0.84 | JAK3 (0.49) | JAK3JAK2HDAC6JAK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |