Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627435 | 0.91 | EGLN1 (0.50) | EGLN1HTTHPGDGLAGAA | |
| SCHEMBL14991893 | 0.89 | EGLN1 (0.52) | EGLN1LMNAHTTKDM4EHPGD | |
| SCHEMBL16626232 | 0.86 | EGLN1 (0.68) | EGLN1LMNAHTTKDM4EHPGD | |
| SCHEMBL623184 | 0.83 | EGLN1 (0.77) | EGLN1 | |
| SCHEMBL14992529 | 0.82 | EGLN1 (0.49) | EGLN1LMNAHTTKDM4EHPGD | |
| SCHEMBL14992352 | 0.79 | EGLN1 (0.52) | EGLN1LMNAHTTKDM4EHPGD | |
| SCHEMBL627008 | 0.79 | HTT (0.50) | EGLN1LMNAHTTKDM4EHPGD | |
| SCHEMBL626993 | 0.79 | EGLN1 (0.50) | EGLN1HPGDGLAGAAHSD17B10 | |
| SCHEMBL16626264 | 0.79 | EGLN1 (0.68) | EGLN1LMNAHTTKDM4EHPGD | |
| SCHEMBL14992310 | 0.77 | EGLN1 (0.48) | EGLN1LMNAHTTMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006251-B2 | 4-aminoquinazolin-2-yl-1-pyrrazole-4-carboxylic acid compounds as prolyl hydroxylase inhibitors | JANSSEN PHARAMCEUTICA NV (BE) | 2015-04-14 | — | — | US | disclosed |