Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 5/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.48 |
| ▸ | JAK3 | P52333 | 13/20 | 0.48 |
| ▸ | JAK1 | P23458 | 9/20 | 0.48 |
| ▸ | JAK2 | O60674 | 7/20 | 0.48 |
| ▸ | TYK2 | P29597 | 6/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12797066 | 0.89 | JAK3 (0.59) | ALKCDK19JAK3JAK1JAK2 | |
| SCHEMBL12959679 | 0.86 | JAK3 (0.48) | ALKCDK19JAK3JAK1JAK2 | |
| SCHEMBL12796610 | 0.86 | JAK3 (0.48) | ALKCDK19JAK3JAK1JAK2 | |
| SCHEMBL12795426 | 0.86 | JAK3 (0.48) | ALKCDK19JAK3JAK1JAK2 | |
| SCHEMBL12797326 | 0.86 | JAK3 (0.48) | ALKCDK19JAK3JAK1JAK2 | |
| SCHEMBL1662896 | 0.86 | JAK3 (0.48) | ALKCDK19JAK3JAK1JAK2 | |
| SCHEMBL12795332 | 0.86 | JAK3 (0.50) | ALKCDK19JAK3JAK1JAK2 | |
| SCHEMBL12801930 | 0.85 | JAK3 (0.48) | ALKCDK19JAK3JAK1JAK2 | |
| SCHEMBL12797104 | 0.84 | JAK3 (0.48) | ALKCDK19JAK3JAK1JAK2 | |
| SCHEMBL12797285 | 0.83 | JAK1 (0.50) | ALKCDK19JAK3JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |