Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16627655 | 0.90 | NPC1 (0.52) | NPC1RAB9ACCR2CNR1CNR2 | |
| SCHEMBL16627643 | 0.90 | NPC1 (0.51) | NPC1RAB9ACCR2CNR1CNR2 | |
| SCHEMBL16627636 | 0.90 | SMN1; SMN2 (0.51) | NPC1RAB9ACCR2CNR1CNR2 | |
| SCHEMBL16627738 | 0.90 | NPC1 (0.58) | NPC1RAB9ACCR2CNR1CNR2 | |
| SCHEMBL16627577 | 0.89 | CNR1 (0.56) | NPC1RAB9AHDAC8HDAC6HDAC1 | |
| SCHEMBL16627736 | 0.89 | NPC1 (0.50) | NPC1RAB9ACCR2CNR1CNR2 | |
| SCHEMBL16627653 | 0.89 | NPC1 (0.50) | NPC1RAB9ACCR2CNR1CNR2 | |
| SCHEMBL16627637 | 0.87 | NPC1 (0.48) | NPC1RAB9ACCR2CNR1CNR2 | |
| SCHEMBL16627684 | 0.86 | PLCG2 (0.48) | NPC1RAB9ACCR2CNR1CNR2 | |
| SCHEMBL16627679 | 0.84 | NPC1 (0.58) | NPC1RAB9ACCR2CNR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015050379-A1 | NOVEL QUINOLINONE DERIVATIVE AND USE THEREOF | 광주과학기술원 | 2015-04-09 | — | — | WO | disclosed |