SCHEMBL16628716

SCHEMBL16628716

COc1ccc2nc(N)nc(C(=O)N3Cc4ccccc4C3)c2c1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 13/20 0.77
HSP90AB1 P08238 3/20 0.71
ADORA3 P0DMS8 1/20 0.47
LMNA P02545 2/20 0.44
MAPT P10636 2/20 0.44
HTT P42858 2/20 0.44
POLB P06746 1/20 0.44
GAA P10253 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
CTSD P07339 1/20 0.44
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
KMT2A Q03164 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43
ALDH1A1 P00352 1/20 0.43
HPGD P15428 1/20 0.43
ALOX15 P16050 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
PLA2G10 O15496 1/20 0.43
PLA2G2A P14555 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28800401 0.89 HSP90AA1 (0.71) HSP90AA1HSP90AB1ADORA3MAPTPOLB
SCHEMBL13144814 0.89 HSP90AA1 (0.71) HSP90AA1HSP90AB1MAPTHTTNPC1
SCHEMBL3081905 0.87 HSP90AA1 (1.00) HSP90AA1HSP90AB1HTTGAACTSD
SCHEMBL13144822 0.86 HSP90AA1 (0.67) HSP90AA1HSP90AB1
SCHEMBL12199578 0.85 HSP90AA1 (1.00) HSP90AA1HSP90AB1ADORA3LMNAMAPT
SCHEMBL16628709 0.84 HSP90AA1 (0.80) HSP90AA1HSP90AB1ADORA3LMNAMAPT
SCHEMBL27869700 0.84 HSP90AA1 (0.65) HSP90AA1HSP90AB1ADORA3POLBL3MBTL1
SCHEMBL12273427 0.84 HSP90AA1 (0.66) HSP90AA1HSP90AB1ADORA3MAPTHTT
SCHEMBL16628686 0.83 HSP90AA1 (1.00) HSP90AA1HSP90AB1HPGDSMN1; SMN2
SCHEMBL12273580 0.83 HSP90AA1 (0.65) HSP90AA1HSP90AB1MAPTHTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2164833-B1 Quinazolinamide derivatives useful for the treatment of tumour diseases MERCK PATENT GMBH (DE) 2015-04-15 EP claimed
EP-2164833-B1 Quinazolinamide derivatives useful for the treatment of tumour diseases MERCK PATENT GMBH (DE) 2015-04-15 EP disclosed