Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16628787 | 1.00 | POLB (0.40) | POLBSMN1; SMN2MAPTALDH1A1ADRB3 | |
| SCHEMBL2843887 | 0.91 | POLB (0.37) | POLBSMN1; SMN2MAPTALDH1A1ADRB3 | |
| SCHEMBL8238400 | 0.91 | POLB (0.37) | POLBSMN1; SMN2MAPTALDH1A1ADRB3 | |
| SCHEMBL2843889 | 0.91 | POLB (0.37) | POLBSMN1; SMN2MAPTALDH1A1ADRB3 | |
| SCHEMBL6760115 | 0.91 | POLB (0.37) | POLBSMN1; SMN2MAPTALDH1A1ADRB3 | |
| SCHEMBL14020643 | 0.89 | POLB (0.38) | POLBSMN1; SMN2MAPTALDH1A1ADRB3 | |
| SCHEMBL313130 | 0.83 | POLB (0.40) | POLBSMN1; SMN2MAPTALDH1A1PTPN2 | |
| SCHEMBL8253707 | 0.81 | ADRB3 (0.32) | ALDH1A1ADRB3ADRA2BADRA2CCTSB | |
| SCHEMBL6823450 | 0.79 | POLB (0.40) | POLBSMN1; SMN2MAPTALDH1A1PTPN2 | |
| SCHEMBL6828088 | 0.79 | POLB (0.40) | POLBSMN1; SMN2MAPTALDH1A1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118091-B1 | PYRIMIDINE SUBSTITUTED MACROCYCLIC HCV INHIBITORS | JANSSEN SCIENCES IRELAND UC (IE) | 2015-04-15 | — | — | EP | disclosed |