Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL553367 | 0.90 | KLKB1 (0.71) | KLKB1 | |
| SCHEMBL554442 | 0.88 | KLKB1 (1.00) | KLKB1 | |
| SCHEMBL27901372 | 0.88 | KLKB1 (0.66) | KLKB1 | |
| SCHEMBL27918957 | 0.88 | KLKB1 (0.66) | KLKB1 | |
| SCHEMBL27901374 | 0.86 | KLKB1 (0.79) | KLKB1 | |
| SCHEMBL12465561 | 0.81 | KLKB1 (0.79) | KLKB1 | |
| SCHEMBL12465569 | 0.78 | KLKB1 (0.79) | KLKB1 | |
| SCHEMBL12465563 | 0.78 | KLKB1 (0.79) | KLKB1 | |
| SCHEMBL554597 | 0.77 | KLKB1 (0.58) | KLKB1 | |
| SCHEMBL554856 | 0.77 | KLKB1 (0.58) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601189-B1 | N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES AS INHIBITORS OF PLASMA KALLIKREIN | NOVARTIS AG (CH) | 2015-04-15 | — | — | EP | disclosed |