Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 18/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 18/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 18/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 17/20 | 0.47 |
| ▸ | TSHR | P16473 | 14/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 12/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 8/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.45 |
| ▸ | LMNA | P02545 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2063881 | 0.80 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL1662668 | 0.77 | MAPK1 (0.33) | TSHRHSD17B10ALDH1A1MAPK1LMNA | |
| SCHEMBL22307623 | 0.75 | CYP1A2 (0.52) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL30555496 | 0.75 | CYP1A2 (0.52) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL22307619 | 0.74 | CYP1A2 (0.58) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL27199466 | 0.72 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL31017360 | 0.72 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL23143391 | 0.69 | CYP1A2 (0.57) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL21174364 | 0.69 | KDM4C (0.52) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL31456984 | 0.69 | KDM4C (0.52) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491032-B1 | AKT INHIBITORS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |
| US-8436002-B2 | AKT inhibitors | ELI LILLY AND COMPANY (US) | 2013-05-07 | — | — | US | disclosed |
| EP-2491032-A1 | AKT INHIBITORS | Eli Lilly and Company (US) | 2012-08-29 | — | — | EP | disclosed |
| US-20120149684-A1 | AKT INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-06-14 | — | — | US | disclosed |
| WO-2011050016-A1 | AKT INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149684-A1 | AKT INHIBITORS | AKT2, PIK3CA, AKT3 | CYP1A2 1674/4885CYP3A4 1467/4885CYP2C19 914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.