Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | FADS1 | O60427 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15352213 | 0.85 | CYP2A6 (0.43) | CYP2A6CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL29792747 | 0.82 | CYP2A6 (0.45) | CYP2A6CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL11584656 | 0.82 | CYP2A6 (0.45) | CYP2A6CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL18015817 | 0.81 | CYP2A6 (0.43) | CYP2A6CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL3571906 | 0.81 | CYP2A6 (0.43) | CYP2A6CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL3570495 | 0.81 | CYP2A6 (0.47) | CYP2A6CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL29792638 | 0.81 | CYP2A6 (0.43) | CYP2A6CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL3276205 | 0.81 | CYP2A6 (0.43) | CYP2A6CYP1A2CYP2C19MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3580262 | 0.79 | CYP2A6 (0.46) | CYP2A6CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL27366935 | 0.78 | CYP2A6 (0.41) | CYP2A6CYP1A2CYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049616-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2015-04-09 | — | — | WO | disclosed |