Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.50 |
| ▸ | ITGAL | P20701 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CRHBP | P24387 | 2/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10589684 | 0.82 | ABCG2 (0.50) | ITGB2ICAM1ITGALLMNAKDM4E | |
| SCHEMBL10589688 | 0.82 | ABCG2 (0.50) | ITGB2ICAM1ITGALLMNAKDM4E | |
| SCHEMBL3072409 | 0.76 | ITGB2 (0.55) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL14439104 | 0.73 | ITGB2 (0.50) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL2306687 | 0.73 | ITGB2 (0.50) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL24312061 | 0.73 | ITGB2 (0.50) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL253657 | 0.73 | ITGB2 (0.50) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL15074801 | 0.73 | ITGB2 (0.50) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL3787577 | 0.73 | ITGB2 (0.50) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL90937 | 0.73 | ITGB2 (0.50) | ITGB2ICAM1ITGALLMNACRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |