Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 14/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 14/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 13/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 13/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 13/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 13/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 13/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10225607 | 0.82 | HDAC1 (0.47) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL1668201 | 0.81 | HDAC6 (0.49) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL1618890 | 0.80 | HDAC1 (0.57) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL10224693 | 0.79 | HDAC6 (0.47) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL10225860 | 0.78 | HDAC6 (0.48) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL1662846 | 0.78 | HDAC6 (0.46) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL10224696 | 0.78 | HDAC6 (0.43) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL1663318 | 0.76 | HDAC6 (0.48) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL1662954 | 0.75 | HDAC6 (0.41) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL1663186 | 0.73 | HDAC6 (0.58) | HDAC6HDAC1HDAC3HDAC2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088754-A1 | SULFONYL-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | EMELEN KRISTOF VAN (BE) | 2012-04-12 | — | — | US | disclosed |
| US-7704998-B2 | anticancer agents; catalytic hydrogenation | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-04-27 | — | — | US | disclosed |
| US-20080108601-A1 | anticancer agents; catalytic hydrogenation | VAN EMELEN KRISTOF | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088754-A1 | SULFONYL-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC3, HDAC1, HDAC11 | HDAC6 8/4885HDAC1 2/4885HDAC3 1/4885 |
| US-20080108601-A1 | anticancer agents; catalytic hydrogenation | HDAC1, HDAC11, HDAC3 | HDAC6 5/4885HDAC1 1/4885HDAC3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.