Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 19/20 | 0.57 |
| ▸ | KRAS | P01116 | 1/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15289659 | 0.89 | KRAS (0.53) | ABL1KRASRAF1BRAFKDR | |
| SCHEMBL16641798 | 0.88 | RAF1 (0.67) | ABL1KRASRAF1BRAFKDR | |
| SCHEMBL15273069 | 0.87 | ABL1 (0.61) | ABL1 | |
| SCHEMBL15270723 | 0.86 | KRAS (0.54) | ABL1KRASRAF1BRAFKDR | |
| SCHEMBL15272563 | 0.85 | RAF1 (0.71) | ABL1KRASRAF1BRAFKDR | |
| SCHEMBL16632189 | 0.85 | RAF1 (0.57) | ABL1KRASRAF1BRAFKDR | |
| SCHEMBL16632262 | 0.85 | RAF1 (0.61) | ABL1KRASRAF1BRAFKDR | |
| Hydrochloric Acid SCHEMBL16632278 | 0.85 | RAF1 (0.70) | ABL1KRASRAF1BRAFKDR | |
| SCHEMBL16632443 | 0.81 | RAF1 (0.55) | ABL1KRASRAF1BRAFKDR | |
| SCHEMBL15272391 | 0.81 | RAF1 (0.58) | ABL1KRASRAF1BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187474-B2 | Raf inhibitor compounds | DECIPHERA PHARMACEUTICALS, LLC (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150105367-A1 | RAF INHIBITOR COMPOUNDS | DECIPHERA PHARMACEUTICALS, LLC | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105367-A1 | RAF INHIBITOR COMPOUNDS | BRAF, RAF1, NRAS | ABL1 56/4885KRAS 4/4885RAF1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.