Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 9/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.44 |
| ▸ | ELANE | P08246 | 4/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24404813 | 0.89 | TLR8 (0.58) | TLR8ALDH1A1GAASMN1; SMN2TLR9 | |
| SCHEMBL16634341 | 0.89 | TLR8 (0.58) | TLR8ALDH1A1GAASMN1; SMN2TLR9 | |
| SCHEMBL16633372 | 0.89 | TLR8 (0.58) | TLR8ALDH1A1GAASMN1; SMN2TLR9 | |
| Hydrochloric Acid SCHEMBL16632234 | 0.88 | TLR8 (0.57) | TLR8ALDH1A1GAASMN1; SMN2TLR9 | |
| Cadaverine Tartrate SCHEMBL16634214 | 0.88 | TLR8 (0.49) | TLR8ALDH1A1GAASMN1; SMN2TLR9 | |
| SCHEMBL19828899 | 0.87 | TLR8 (0.50) | TLR8ALDH1A1GAASMN1; SMN2TLR9 | |
| SCHEMBL24404811 | 0.87 | TLR8 (0.50) | TLR8ALDH1A1GAASMN1; SMN2TLR9 | |
| SCHEMBL16646454 | 0.87 | TLR8 (0.50) | TLR8ALDH1A1GAASMN1; SMN2TLR9 | |
| SCHEMBL24404821 | 0.87 | TLR8 (0.50) | TLR8ALDH1A1GAASMN1; SMN2TLR9 | |
| SCHEMBL16634023 | 0.87 | TLR8 (0.52) | TLR8ALDH1A1GAASMN1; SMN2TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3626717-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | Eisai R&D Management Co., Ltd. (JP) | 2020-03-25 | — | — | EP | claimed |
| US-RE47193-E1 | Selectively substituted quinoline compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2019-01-08 | — | — | US | claimed |
| US-20160326161-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-11-10 | — | — | US | claimed |
| US-9428495-B2 | Selectively substituted quinoline compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-08-30 | — | — | US | claimed |
| US-20150105370-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-16 | — | — | US | claimed |
| EP-3995495-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | Eisai R&D Management Co., Ltd. (JP) | 2022-05-11 | — | — | EP | disclosed |
| EP-3626717-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | Eisai R&D Management Co., Ltd. (JP) | 2020-03-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326161-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | SSB, TLR7, TLR8 | TLR8 3/4885ALDH1A1 4592/4885GAA 3126/4885 |
| US-20150105370-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | SSB, TLR7, TLR8 | TLR8 3/4885ALDH1A1 4592/4885GAA 3126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.