SCHEMBL16636831

SCHEMBL16636831

NC(=O)C1CN(c2ncnc3cc(Cl)c(-c4ccc(Cl)cc4)cc23)CCN1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 6/20 0.46
CLK4 Q9HAZ1 2/20 0.42
CYP1A2 P05177 2/20 0.42
LMNA P02545 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C19 P33261 1/20 0.42
KIT P10721 4/20 0.38
AKT1 P31749 2/20 0.38
PDGFRB P09619 1/20 0.38
PDGFRA P16234 1/20 0.38
USP2 O75604 1/20 0.38
TSHR P16473 1/20 0.38
HSD17B10 Q99714 1/20 0.38
PRKDC P78527 1/20 0.37
JAK1 P23458 1/20 0.37
FPR2 P25090 1/20 0.37
SCN9A Q15858 1/20 0.37
CYP2D6 P10635 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16647244 1.00 PDE10A (0.46) PDE10ACLK4CYP1A2LMNACYP3A4
SCHEMBL16647229 0.91 PDE10A (0.47) PDE10ACLK4CYP1A2LMNACYP3A4
SCHEMBL16647209 0.88 PDE10A (0.50) PDE10ACLK4CYP1A2LMNACYP3A4
SCHEMBL16636912 0.86 PDE10A (0.44) PDE10ACLK4CYP1A2LMNACYP3A4
SCHEMBL16647132 0.83 PDE10A (0.48) PDE10ACLK4CYP1A2LMNACYP3A4
SCHEMBL16647257 0.83 PDE10A (0.48) PDE10ACLK4CYP1A2LMNACYP3A4
Hydrochloric Acid SCHEMBL16637062 0.83 PDE10A (0.47) PDE10ACLK4CYP1A2LMNACYP3A4
Hydrochloric Acid SCHEMBL28448898 0.83 PDE10A (0.46) PDE10ACLK4CYP1A2LMNACYP3A4
SCHEMBL17030831 0.82 PRKDC (0.57) CYP1A2CYP3A4CYP2C19HSD17B10PRKDC
SCHEMBL16637456 0.82 PDE10A (0.47) PDE10ACLK4CYP1A2LMNACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2025-02-25 US disclosed
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-10-24 US disclosed
US-20240043441-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-02-08 US disclosed
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2024-01-23 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20220242875-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2022-08-04 US disclosed
US-20210188869-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2021-06-24 US disclosed
EP-3193851-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER Araxes Pharma LLC (US) 2017-07-26 EP disclosed
EP-3055290-A1 INHIBITORS OF KRAS G12C Araxes Pharma LLC (US) 2016-08-17 EP disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210188869-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS PDE10A 3299/4885CLK4 1823/4885CYP1A2 3408/4885
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C KRAS, NRAS, HRAS PDE10A 2784/4885CLK4 1579/4885CYP1A2 4341/4885
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C KRAS, NRAS, HRAS PDE10A 3998/4885CLK4 598/4885CYP1A2 1845/4885
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS PDE10A 3998/4885CLK4 598/4885CYP1A2 1845/4885
US-20150239900-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS PDE10A 3299/4885CLK4 1823/4885CYP1A2 3408/4885
US-20230212183-A9 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS PDE10A 3299/4885CLK4 1823/4885CYP1A2 3408/4885
US-20240043441-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS PDE10A 3299/4885CLK4 1823/4885CYP1A2 3408/4885
US-20230303586-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS PDE10A 3299/4885CLK4 1823/4885CYP1A2 3408/4885
US-20220242875-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS PDE10A 3299/4885CLK4 1823/4885CYP1A2 3408/4885
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER KRAS, TP53, HRAS PDE10A 4346/4885CLK4 3224/4885CYP1A2 4679/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.