SCHEMBL16636960

SCHEMBL16636960

Cc1nc(N2CCN(C(=O)OC(C)(C)C)C(C(N)=O)C2)c2cc(-c3ccc(Cl)cc3)c(Cl)cc2n1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
EIF2AK4 Q9P2K8 1/20 0.39
KRAS P01116 1/20 0.36
ALDH1A1 P00352 1/20 0.36
DPP4 P27487 1/20 0.36
NR1H2 P55055 4/20 0.35
NR1H3 Q13133 4/20 0.35
CNR1 P21554 1/20 0.35
CNR2 P34972 1/20 0.35
MAP4K4 O95819 1/20 0.35
TLR9 Q9NR96 1/20 0.35
SUV39H2 Q9H5I1 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.34
BACE1 P56817 1/20 0.34
GRM2 Q14416 1/20 0.34
JAK2 O60674 1/20 0.34
UCHL1 P09936 1/20 0.34
USP30 Q70CQ3 1/20 0.34
ABL1 P00519 1/20 0.34
BCR P11274 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29765871 1.00 EIF2AK4 (0.39) EIF2AK4KRASALDH1A1DPP4NR1H2
SCHEMBL22560917 0.89 MAP4K4 (0.40) EIF2AK4KRASCNR1CNR2MAP4K4
SCHEMBL29765684 0.89 MAP4K4 (0.40) EIF2AK4KRASCNR1CNR2MAP4K4
SCHEMBL17026606 0.89 MAP4K4 (0.40) EIF2AK4KRASCNR1CNR2MAP4K4
SCHEMBL16637209 0.89 MAP4K4 (0.40) EIF2AK4KRASCNR1CNR2MAP4K4
SCHEMBL29765753 0.89 MAP4K4 (0.40) EIF2AK4KRASCNR1CNR2MAP4K4
SCHEMBL16637112 0.88 KRAS (0.37) KRASCNR1CNR2GRM2
SCHEMBL16646962 0.87 KRAS (0.39) KRASDPP4NR1H2NR1H3CNR1
SCHEMBL16637083 0.85 EIF2AK4 (0.39) EIF2AK4KRASALDH1A1NR1H2NR1H3
SCHEMBL16647170 0.84 TLR9 (0.49) KRASDPP4NR1H2NR1H3CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2025-02-25 US disclosed
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-10-24 US disclosed
US-20240043441-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-02-08 US disclosed
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2024-01-23 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20220242875-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2022-08-04 US disclosed
US-20210188869-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2021-06-24 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210188869-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2812/4885KRAS 1/4885ALDH1A1 4178/4885
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2589/4885KRAS 1/4885ALDH1A1 3870/4885
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2112/4885KRAS 1/4885ALDH1A1 4009/4885
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2112/4885KRAS 1/4885ALDH1A1 4009/4885
US-20150239900-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2812/4885KRAS 1/4885ALDH1A1 4178/4885
US-20230212183-A9 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2812/4885KRAS 1/4885ALDH1A1 4178/4885
US-20240043441-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2812/4885KRAS 1/4885ALDH1A1 4178/4885
US-20230303586-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2812/4885KRAS 1/4885ALDH1A1 4178/4885
US-20220242875-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS EIF2AK4 2812/4885KRAS 1/4885ALDH1A1 4178/4885
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER KRAS, TP53, HRAS EIF2AK4 1068/4885KRAS 1/4885ALDH1A1 1577/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.