Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A | Q12879 | 10/20 | 0.76 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.76 |
| ▸ | GRIA2 | P42262 | 7/20 | 0.76 |
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17971451 | 0.91 | GRIN2A (0.84) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16645770 | 0.88 | GRIN2A (0.81) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL17975699 | 0.88 | GRIN2A (0.81) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16645771 | 0.87 | GRIN2A (0.84) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16636309 | 0.87 | GRIN2A (1.00) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16636699 | 0.87 | GRIN2A (1.00) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16636514 | 0.87 | GRIN2A (1.00) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL17958136 | 0.86 | GRIN2A (0.76) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16645769 | 0.86 | GRIN2A (0.76) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL17958209 | 0.85 | GRIN2A (0.78) | GRIN2AGRIN1GRIA2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055315-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |