SCHEMBL16637144

SCHEMBL16637144

CC(C)(C)OC(=O)N1CCN(c2ncnc3cc(Cl)c(Br)cc23)CC1C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAP4K4 O95819 1/20 0.40
KIT P10721 2/20 0.39
PDGFRB P09619 9/20 0.38
PDGFRA P16234 4/20 0.37
NR1H2 P55055 2/20 0.36
NR1H3 Q13133 1/20 0.36
KRAS P01116 3/20 0.36
ACHE P22303 1/20 0.36
BACE1 P56817 1/20 0.36
FLT3 P36888 1/20 0.35
PDE10A Q9Y233 1/20 0.35
HTR1A P08908 1/20 0.35
HTR7 P34969 1/20 0.35
MAPK1 P28482 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16636620 0.92 MAP4K4 (0.41) MAP4K4KITPDGFRBPDGFRANR1H2
SCHEMBL16636969 0.91 NR1H2 (0.47) MAP4K4KITPDGFRBPDGFRANR1H2
SCHEMBL16637087 0.87 NR1H2 (0.36) MAP4K4NR1H2NR1H3KRAS
SCHEMBL16636798 0.85 CNR1 (0.41) MAP4K4KITPDGFRBPDGFRAKRAS
SCHEMBL16636796 0.85 CNR1 (0.41) MAP4K4KITPDGFRBPDGFRAKRAS
SCHEMBL30902163 0.83 KIT (0.52) MAP4K4KITPDGFRBPDGFRAACHE
SCHEMBL16637110 0.83 KIT (0.52) MAP4K4KITPDGFRBPDGFRAACHE
SCHEMBL16637242 0.80 KRAS (0.39) PDGFRBPDGFRAKRASACHEBACE1
SCHEMBL29765688 0.80 MAP4K4 (0.40) MAP4K4KITNR1H2NR1H3KRAS
SCHEMBL16637206 0.80 MAP4K4 (0.40) MAP4K4KITNR1H2NR1H3KRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2025-02-25 US disclosed
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-10-24 US disclosed
US-20240043441-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-02-08 US disclosed
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2024-01-23 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20220242875-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2022-08-04 US disclosed
US-20210188869-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2021-06-24 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210188869-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MAP4K4 559/4885KIT 4380/4885PDGFRB 1746/4885
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C KRAS, NRAS, HRAS MAP4K4 568/4885KIT 4086/4885PDGFRB 575/4885
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C KRAS, NRAS, HRAS MAP4K4 266/4885KIT 3330/4885PDGFRB 1938/4885
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MAP4K4 266/4885KIT 3330/4885PDGFRB 1938/4885
US-20150239900-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MAP4K4 559/4885KIT 4380/4885PDGFRB 1746/4885
US-20230212183-A9 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MAP4K4 559/4885KIT 4380/4885PDGFRB 1746/4885
US-20240043441-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MAP4K4 559/4885KIT 4380/4885PDGFRB 1746/4885
US-20230303586-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MAP4K4 559/4885KIT 4380/4885PDGFRB 1746/4885
US-20220242875-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS MAP4K4 559/4885KIT 4380/4885PDGFRB 1746/4885
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER KRAS, TP53, HRAS MAP4K4 1204/4885KIT 2636/4885PDGFRB 592/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.