Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A | Q12879 | 20/20 | 0.72 |
| ▸ | GRIN1 | Q05586 | 19/20 | 0.72 |
| ▸ | GRIA2 | P42262 | 17/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16645874 | 0.86 | GRIN2A (0.81) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16636288 | 0.85 | GRIN2A (0.81) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16636275 | 0.85 | GRIN2A (0.77) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16636283 | 0.85 | GRIN2A (0.77) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645574 | 0.85 | GRIN2A (0.81) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645444 | 0.84 | GRIN2A (0.86) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16636719 | 0.84 | GRIN2A (1.00) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645778 | 0.83 | GRIN2A (0.75) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645537 | 0.83 | GRIN2A (0.70) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645569 | 0.83 | GRIN2A (0.70) | GRIN2AGRIN1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055315-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |