Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 19/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 10/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1661730 | 0.81 | S1PR1 (0.66) | S1PR1S1PR3 | |
| SCHEMBL1661710 | 0.77 | S1PR1 (0.60) | S1PR1S1PR3 | |
| SCHEMBL1662175 | 0.76 | S1PR1 (0.55) | S1PR1S1PR3 | |
| SCHEMBL1663763 | 0.75 | S1PR1 (0.53) | S1PR1S1PR3 | |
| SCHEMBL3423992 | 0.74 | S1PR1 (0.55) | S1PR1S1PR3 | |
| SCHEMBL1663747 | 0.74 | S1PR1 (0.52) | S1PR1S1PR3 | |
| SCHEMBL1661299 | 0.72 | S1PR1 (0.52) | S1PR1S1PR3 | |
| SCHEMBL15163447 | 0.72 | S1PR1 (0.69) | S1PR1S1PR3 | |
| SCHEMBL3419846 | 0.72 | S1PR1 (0.69) | S1PR1S1PR3 | |
| SCHEMBL1661974 | 0.72 | S1PR1 (0.69) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |