Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD1 | Q13393 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1140766 | 0.74 | PLD1 (0.47) | PLD1EP300KAT2BALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3827230 | 0.72 | PLD1 (0.46) | PLD1EP300KAT2BALDH1A1HPGD | |
| Bromide SCHEMBL6883560 | 0.71 | PLD1 (0.44) | PLD1EP300KAT2BALDH1A1HPGD | |
| SCHEMBL30569109 | 0.69 | PLD1 (0.50) | PLD1EP300KAT2BALDH1A1HPGD | |
| SCHEMBL1437298 | 0.69 | PLD1 (0.50) | PLD1EP300KAT2BALDH1A1HPGD | |
| SCHEMBL27508033 | 0.68 | PLD1 (0.46) | PLD1ALDH1A1HPGDHSD17B10CRBN | |
| Ammonia Solution, Strong SCHEMBL28277848 | 0.67 | PLD1 (0.48) | PLD1EP300KAT2BALDH1A1HPGD | |
| SCHEMBL30565007 | 0.67 | PLD1 (0.44) | PLD1ALDH1A1HPGDHSD17B10CRBN | |
| SCHEMBL6499166 | 0.67 | PLD1 (0.44) | PLD1EP300KAT2BALDH1A1HPGD | |
| SCHEMBL2096767 | 0.67 | PLD1 (0.44) | PLD1ALDH1A1HPGDHSD17B10CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055301-A1 | RHO KINASE INHIBITORS | Kadmon Corporation, LLC (US) | 2016-08-17 | — | — | EP | claimed |
| WO-2015054317-A1 | RHO KINASE INHIBITORS | KADMON CORPORATION, LLC (US) | 2015-04-16 | — | — | WO | claimed |
| CN-101817836-B | Method for preparing imidazo[2,1-b]thiazole derivative by catalysis of copper salt | UNIV ZHEJIANG | 2012-02-29 | — | — | CN | disclosed |
| CN-101817836-A | Method for preparing imidazo[2,1-b]thiazole derivative by catalysis of copper salt | UNIV ZHEJIANG | 2010-09-01 | — | — | CN | disclosed |