Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4C | Q08493 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 3/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 3/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL722839 | 0.88 | PDE4C (0.51) | PDE4CHPGDALDH1A1KDM4EJAK2 | |
| SCHEMBL723093 | 0.88 | PDE4C (0.55) | PDE4CHPGDALDH1A1KDM4EJAK2 | |
| SCHEMBL723597 | 0.88 | FYN (0.54) | PDE4CALDH1A1JAK2JAK1TYK2 | |
| SCHEMBL10267650 | 0.88 | FYN (0.54) | PDE4CALDH1A1JAK2JAK1TYK2 | |
| SCHEMBL16638610 | 0.87 | PDE4C (0.47) | PDE4CALDH1A1JAK2JAK1TYK2 | |
| SCHEMBL723624 | 0.86 | PDE4C (0.47) | PDE4CALDH1A1JAK2JAK1TYK2 | |
| SCHEMBL724163 | 0.85 | HPGD (0.40) | HPGDALDH1A1TSHRHSD17B10KDM4E | |
| SCHEMBL722271 | 0.85 | PDE4C (0.48) | PDE4CJAK2JAK1TYK2JAK3 | |
| SCHEMBL722497 | 0.85 | PDE4C (0.47) | PDE4CJAK2JAK1TYK2JAK3 | |
| SCHEMBL722343 | 0.85 | PDE4C (0.47) | PDE4CHPGDALDH1A1KDM4EJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |