Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.70 |
| ▸ | PDE6D | O43924 | 1/20 | 0.56 |
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
| ▸ | PDE6A | P16499 | 1/20 | 0.56 |
| ▸ | PDE6G | P18545 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE6B | P35913 | 1/20 | 0.56 |
| ▸ | PDE6C | P51160 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6900533 | 0.88 | PDE10A (0.71) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL14211805 | 0.85 | PDE10A (0.73) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL6899512 | 0.85 | PDE10A (0.54) | PDE10AALDH1A1NPC1HPGDRAB9A | |
| SCHEMBL14120049 | 0.84 | PDE10A (0.66) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL6899491 | 0.84 | PDE10A (0.69) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL14211793 | 0.84 | PDE10A (0.69) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL14211803 | 0.84 | PDE10A (0.72) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL14119732 | 0.84 | PDE10A (0.72) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL6900869 | 0.83 | PDE10A (1.00) | PDE10APDE6DPDE5APDE6APDE6G | |
| Hydrochloric Acid SCHEMBL14119954 | 0.83 | PDE10A (0.73) | PDE10APDE6DPDE5APDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539342-B1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2015-04-15 | — | — | EP | disclosed |