Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 19/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14211897 | 0.93 | PDE10A (0.81) | PDE10AKDM4EUSP2LMNAMAPT | |
| SCHEMBL2438043 | 0.82 | PDE10A (1.00) | PDE10AKDM4EUSP2LMNAMAPT | |
| SCHEMBL14211874 | 0.80 | PDE10A (0.80) | PDE10AKDM4EUSP2LMNAMAPT | |
| SCHEMBL14211888 | 0.77 | PDE10A (0.62) | PDE10A | |
| SCHEMBL6900520 | 0.75 | PDE10A (0.88) | PDE10AKDM4EUSP2LMNAMAPT | |
| SCHEMBL2439865 | 0.75 | PDE10A (0.72) | PDE10ATSHR | |
| SCHEMBL6901208 | 0.75 | PDE10A (0.76) | PDE10AKDM4EUSP2LMNAMAPT | |
| SCHEMBL6898062 | 0.72 | PDE10A (0.68) | PDE10AKDM4ELMNAMAPTTSHR | |
| SCHEMBL2408367 | 0.71 | PDE10A (0.81) | PDE10A | |
| Hydrochloric Acid SCHEMBL2407259 | 0.71 | PDE10A (0.81) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539342-B1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2015-04-15 | — | — | EP | disclosed |