Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 3/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | PDE6D | O43924 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDE6A | P16499 | 1/20 | 0.37 |
| ▸ | PDE6G | P18545 | 1/20 | 0.37 |
| ▸ | PDE6B | P35913 | 1/20 | 0.37 |
| ▸ | PDE6C | P51160 | 1/20 | 0.37 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14211862 | 0.91 | PDE10A (0.74) | PDE10A | |
| SCHEMBL6899838 | 0.84 | PDE10A (0.70) | PDE10ARAB9APDE4APDE4BPDE4C | |
| SCHEMBL16639189 | 0.82 | PDE10A (0.62) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6899535 | 0.80 | PDE10A (0.72) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6900737 | 0.80 | PDE10A (0.84) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14211848 | 0.78 | PDE10A (0.74) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14211894 | 0.78 | PDE10A (0.63) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14211888 | 0.78 | PDE10A (0.62) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6900743 | 0.78 | PDE10A (0.75) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14211787 | 0.77 | PDE10A (0.68) | PDE10APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539342-B1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2015-04-15 | — | — | EP | disclosed |