Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 17/20 | 0.78 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | PDE6D | O43924 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PDE6A | P16499 | 1/20 | 0.45 |
| ▸ | PDE6G | P18545 | 1/20 | 0.45 |
| ▸ | PDE6B | P35913 | 1/20 | 0.45 |
| ▸ | PDE6C | P51160 | 1/20 | 0.45 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2441808 | 0.88 | PDE10A (1.00) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2442700 | 0.83 | PDE10A (1.00) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14211902 | 0.78 | PDE10A (0.82) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14211850 | 0.76 | PDE10A (0.81) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16639189 | 0.76 | PDE10A (0.62) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14211849 | 0.74 | PDE10A (0.67) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14211899 | 0.73 | PDE10A (0.74) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14211903 | 0.73 | PDE10A (0.82) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6900737 | 0.73 | PDE10A (0.84) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6900536 | 0.72 | PDE10A (0.58) | PDE10APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539342-B1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2015-04-15 | — | — | EP | disclosed |