Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 18/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 15/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1661871 | 0.85 | S1PR1 (0.59) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1661072 | 0.72 | S1PR1 (0.61) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1663753 | 0.70 | S1PR1 (0.62) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1662117 | 0.69 | S1PR1 (0.55) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1661634 | 0.69 | S1PR1 (0.61) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1661630 | 0.69 | S1PR1 (0.75) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1661295 | 0.69 | S1PR1 (0.58) | S1PR1S1PR3S1PR5 | |
| SCHEMBL10077188 | 0.69 | S1PR5 (0.46) | S1PR1S1PR5 | |
| SCHEMBL1281271 | 0.68 | KDM4E (0.49) | S1PR1S1PR5 | |
| SCHEMBL10077200 | 0.68 | S1PR5 (0.47) | S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |