Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664696 | 0.95 | MCHR1 (0.52) | MAPTSMN1; SMN2NPC1RAB9AMCHR1 | |
| SCHEMBL1664084 | 0.94 | MCHR1 (0.54) | MAPTSMN1; SMN2NPC1RAB9AMCHR1 | |
| SCHEMBL1666916 | 0.90 | MAPT (0.52) | MAPTSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL1664703 | 0.89 | MCHR1 (0.61) | MAPTSMN1; SMN2NPC1RAB9AMCHR1 | |
| SCHEMBL1666799 | 0.87 | MAPT (0.53) | MAPTSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL1664395 | 0.86 | MAPT (0.50) | MAPTSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL1666114 | 0.85 | MAPT (0.51) | MAPTSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL6125796 | 0.85 | MAPT (0.50) | MAPTSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL1664235 | 0.84 | MAPT (0.49) | MAPTSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL1665038 | 0.84 | MAPT (0.49) | MAPTSMN1; SMN2NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |