Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.50 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | CTSE | P14091 | 1/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2520360 | 1.00 | BACE1 (0.50) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL15418810 | 0.87 | BACE1 (0.44) | BACE1KCNH2CTSD | |
| SCHEMBL15418623 | 0.86 | BACE1 (0.48) | BACE1KCNH2CTSD | |
| SCHEMBL15418727 | 0.85 | BACE1 (0.47) | BACE1KCNH2CTSD | |
| SCHEMBL2523979 | 0.83 | BACE1 (0.65) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL2523423 | 0.83 | BACE1 (0.65) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL2520352 | 0.80 | BACE1 (0.63) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL2520346 | 0.80 | BACE1 (0.63) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL2523399 | 0.78 | BACE1 (0.64) | BACE1KCNH2CTSD | |
| SCHEMBL2525830 | 0.78 | BACE1 (0.64) | BACE1KCNH2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012446-B2 | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2015-04-21 | — | — | US | disclosed |